Sensitive and efficient detection of drug-resistant mutations is essential in cancer precision medicine.In treating acute myeloid leukemia (AML), FLT3 gene F691L mutation shows universal resistance to all currently fr5457 available FLT3 inhibitors.However, there is no particular detection method for FLT3-F691L.Commonly-used first-generation sequenc
According to the of alignment and entrenchment theories, the CEO power may lead to a reduction audit fees by increasing the earning quality and reducing audit risk, or through opportunistic earnings management and fraudulent financial reporting can lead to increased agency problems and audit risk, and ultimately to increased audit fees.Therefore, t
A method for improving radar-derived quantitative precipitation estimation is proposed.Tropical vertical profiles of reflectivity (VPRs) are first determined from multiple VPRs.Upon identifying a tropical VPR, the event can be further classified as either tropical-stratiform or tropical-convective rainfall by a fuzzy logic (FL) algorithm.Based on t